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OBJECTIVES: To evaluate the association between protein intake and incident frailty.

DESIGN: Prospective cohort study.

SETTING: Subset of the Women's Health Initiative Observational Study conducted at 40 clinical centers.

PARTICIPANTS: Twenty‐four thousand four hundred seventeen women aged 65 to 79 who were free of frailty at baseline with plausible self‐reported energy intakes (600–5,000 kcal/day) according to the Food Frequency Questionnaire (FFQ).

MEASUREMENTS: Baseline protein intake was estimated from the FFQ. Calibrated estimates of energy and protein intake were corrected for measurement error using regression calibration equations estimated from objective measures of total energy expenditure (doubly labeled water) and dietary protein (24‐hour urinary nitrogen). After 3 years of follow‐up, frailty was defined as having at least three of the following components: low physical …