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The immunological response during early human Trypanosoma cruzi infection is not completely understood, despite its role in driving the development of distinct clinical manifestations of chronic infection. Herein we report the results of a descriptive flow cytometric immunophenotyping investigation of major and minor peripheral blood leucocyte subpopulations in T. cruzi-infected children, characterizing the early stages of the indeterminate clinical form of Chagas’ disease. Our results indicated significant alterations by comparison with uninfected children, including increased values of pre-natural killer (NK)-cells (CD3^– CD16⁺ CD56^–), and higher values of proinflammatory monocytes (CD14⁺ CD16⁺ HLA-DR⁺⁺). The higher values of activated B lymphocytes (CD19⁺ CD23⁺) contrasted with impaired T cell activation, indicated by lower values of CD4⁺ CD38⁺ and CD4⁺ HLA-DR⁺ lymphocytes, a lower …