作者
Subramanian Venkataraman, Vivek Mohan, Balakrishnan S Ramakrishna, Shajan Peter, Ashok Chacko, George Chandy, George Kurian, Susy Kurian, Minnie Mathan, Vadakkenadayil I Mathan, Susama Patra, Anna Pulimood, David Dk Rolston
发表日期
2005/5
期刊
Journal of gastroenterology and hepatology
卷号
20
期号
5
页码范围
705-709
出版商
Blackwell Science Pty
简介
Background: The risk for colorectal cancer (CRC) in ulcerative colitis (UC) in India is not known.
Method: Retrospective cohort from a tertiary level hospital in South India. Analysis of archived records of all patients with UC who underwent colonoscopy and segmental biopsies over the last 25 years. Incidence densities and risk of developing high grade dysplasia or CRC was calculated and chi‐squared test was performed for risk factors of interest.
Results: Complete records were available for 532 patients, 336 (63.2%) male. The mean (± SEM) duration of illness was 6.04 ± 0.29 years. In total, 234 patients (44%) had pancolitis, 121 (22.7%) had left‐sided colitis and 177 (33.3%) had proctitis or proctosigmoiditis. Overall, five (0.94%) patients developed carcinoma and one (0.19%) patient had high grade dysplasia. The incidence density and risk of developing either CRC or high grade dysplasia was zero in …
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S Venkataraman, V Mohan, BS Ramakrishna, S Peter… - Journal of gastroenterology and hepatology, 2005