作者
Yujun Shao, Chantelle M Wolpert, Kimberly L Raiford, Marisa M Menold, Shannon L Donnelly, Sarah A Ravan, Meredyth P Bass, Cate McClain, Lennart von Wendt, Jeffery M Vance, Ruth H Abramson, Harry H Wright, Allison Ashley‐Koch, John R Gilbert, Robert G DeLong, Michael L Cuccaro, Margaret A Pericak‐Vance
发表日期
2002/1/8
期刊
American journal of medical genetics
卷号
114
期号
1
页码范围
99-105
出版商
John Wiley & Sons, Inc.
简介
Autistic disorder (AutD) is a neurodevelopmental disorder characterized by significant impairment in social, communicative, and behavioral functioning. A genetic basis for AutD is well established with as many as 10 genes postulated to contribute to its underlying etiology. We have completed a genomic screen and follow‐up analysis to identify potential AutD susceptibility loci. In stage one of the genome screen, 52 multiplex families (two or more AutD affected individuals/family) were genotyped with 352 genetic markers to yield an approximately 10 centimorgan (cM) grid, inclusive of the X chromosome. The selection criterion for follow‐up of interesting regions was a maximum heterogeneity lod score (MLOD) or a maximum nonparametric sib pair lod score (MLS) of at least 1.0. Eight promising regions were identified on chromosomes 2, 3, 7, 15, 18, 19, and X. In the stage two follow‐up study we analyzed an …
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Y Shao, CM Wolpert, KL Raiford, MM Menold… - American journal of medical genetics, 2002