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A collagen/poly(2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt) (collagen/PNaAMPS) interpenetrating polymer network (IPN) hydrogel was prepared by simultaneous reaction of EDC/NHS-mediated crosslinking of concentrated collagen solution and poly(ethylene glycol) diacrylate crosslinking NaAMPS in a sealed syringe. The collagen/PNaAMPS hydrogels were freeze-dried and immersed in an aqueous solution of PDMAEMA-capped ZnO quantum dots (QDs) to construct a ZnO QDs-laden collagen/PNaAMPS IPN hydrogel. The composite hydrogel containing nearly 90% water exhibited light transmission from 85% to 96%. Introducing the PNaAMPS network considerably improved the mechanical strength of the pristine collagen gel, whereas loading ZnO QDs only slightly affected the optical properties, mechanical properties and water absorption. Strikingly, the loaded ZnO QDs were found to serve …