作者
Thomas R Wade, Henry E Jones, Joseph J Chanda
发表日期
1979/7/1
期刊
Archives of Internal Medicine
卷号
139
期号
7
页码范围
784-786
出版商
American Medical Association
简介
The efficacy and safety of intravenously administered miconazole nitrate was examined in eight patients with the following infections: cutaneous North American blastomycosis (one), extensive dermatophytosis (one), and chronic mucocutaneous candidiasis (six). Mycologic assessment included direct examination for fungal elements, fungal culture, and histopathology. Laboratory evaluations were performed before and at regular intervals during the study. The total miconazole nitrate dosage, which was administered over a seven- to 32-day period, ranged from 4.0 to 46.8 g. Follow-up examinations extended from two to 15 months. Excellent results were obtained in five patients and fair results in three. No renal, cardiac, hepatic, or hematopoietic toxicity was observed. Other side effects, however, necessitated premature cessation of therapy in four patients. Overall, intravenously administered miconazole is an …
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TR Wade, HE Jones, JJ Chanda - Archives of Internal Medicine, 1979