作者
Carole Ayoub Moubareck, Dalal Hammoudi Halat, Anju Nabi, Mouza A AlSharhan, Zulfa O AlDeesi, Aaron Han, Handan Celiloglu, Dolla Karam Sarkis
发表日期
2021
期刊
Journal of global antimicrobial resistance
卷号
24
页码范围
27
出版商
Elsevier BV
简介
Acinetobacter baumannii is a Gram-negative organism that has become a significant offender in health-care facilities, with the worldwide spread of carbapenem-resistant Acinetobacter baumannii (CRAB) significantly debilitating treatment options. Acquired carbapenemases of Ambler class D, or oxacillinases, namely OXA-23-like, OXA-24-like, OXA-58-like, OXA-143-like and OXA-235-like groups, have been largely described in CRAB. Non-OXA carbapenemases are also acquired by A. baumannii, including metallo-β-lactamases of Ambler class B, such as the NDM-group, as well as Ambler class A carbapenemases, KPC and GES [1]. Intrinsically, two β-lactam hydrolysing enzyme groups occur in CRAB, OXA-51 and Acinetobacter-derived cephalosporinases (ADCs). While these two intrinsic enzyme categories secure weak carbapenem hydrolysis, acquisition of insertion sequence (IS) elements such as ISAba1 …
引用总数
20212022202320241311
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