作者
Giovanni Babini, Luigi Grassi, Ilaria Russo, Deborah Novelli, Antonio Boccardo, Anita Luciani, Francesca Fumagalli, Lidia Staszewsky, Fabio Fiordaliso, Marcella De Maglie, Monica Salio, Davide D Zani, Teresa Letizia, Serge Masson, Mario V Luini, Davide Pravettoni, Eugenio Scanziani, Roberto Latini, Giuseppe Ristagno
发表日期
2018/2/1
期刊
Shock
卷号
49
期号
2
页码范围
205-212
出版商
LWW
简介
Methods:
An established model of myocardial infarction followed by CA and cardiopulmonary resuscitation was used. Twenty-two pigs were subjected to three no-flow durations: short (8–10 min), intermediate (12–13 min), and long (14–15 min). Left ventricular ejection fraction (LVEF) was assessed together with thermodilution cardiac output (CO) and high sensitivity cardiac troponin T (hs-cTnT). Neurological impairment was evaluated by neurological scores, serum neuron specific enolase (NSE), and histopathology.
Results:
More than 60% of animals survived when the duration of CA was≤ 13 min, compared to only 20% for a duration≥ 14 min. Neuronal degeneration and neurological scores showed a trend toward a worse recovery for longer no-flow durations. No animals achieved a good neurological recovery for a no-flow≥ 14 min, in comparison to a 56% for a duration≤ 13 min (P= 0.043). Serum NSE levels …
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G Babini, L Grassi, I Russo, D Novelli, A Boccardo… - Shock, 2018