作者
Molebogeng X Rangaka, Katalin A Wilkinson, Judith R Glynn, Daphne Ling, Dick Menzies, Judith Mwansa-Kambafwile, Katherine Fielding, Robert J Wilkinson, Madhukar Pai
发表日期
2012/1/1
来源
The Lancet infectious diseases
卷号
12
期号
1
页码范围
45-55
出版商
Elsevier
简介
Background
We aimed to assess whether interferon-γ release assays (IGRAs) can predict the development of active tuberculosis and whether the predictive ability of these tests is better than that of the tuberculin skin test (TST).
Methods
Longitudinal studies of the predictive value for active tuberculosis of in-house or commercial IGRAs were identified through searches of PubMed, Embase, Biosis, and Web of Science and complementary manual searches up to June 30, 2011. Eligible studies included adults or children, with or without HIV, who were free of active tuberculosis at study baseline. We summarised incidence rates in forest plots and pooled data with random-effects models when appropriate. We calculated incidence rate ratios (IRR) for rates of disease progression in IGRA-positive versus IGRA-negative individuals.
Findings
15 studies had a combined sample size of 26 680 participants. Incidence of …
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