作者
Dorothea Evers, Rutger A Middelburg, Masja de Haas, Saurabh Zalpuri, Karen MK de Vooght, Daan van de Kerkhof, Otto Visser, Nathalie C Péquériaux, Francisca Hudig, Henk Schonewille, Jaap Jan Zwaginga, Johanna G van der Bom
发表日期
2016/6/1
期刊
The Lancet Haematology
卷号
3
期号
6
页码范围
e284-e292
出版商
Elsevier
简介
Background
Matching donor red blood cells based on recipient antigens prevents alloimmunisation. Knowledge about the immunogenicity of red-blood-cell antigens can help optimise risk-adapted matching strategies. We set out to assess the immunogenicity of red-blood-cell antigens.
Methods
In an incident new-user cohort of previously non-transfused, non-alloimmunised white patients receiving non-extended matched red-blood-cell transfusions in six Dutch hospitals between 2006 and 2013, we determined the cumulative number of mismatched red-blood-cell units per patient. We used multiple imputation to address missing antigen data. Using Kaplan-Meier analysis, we estimated cumulative alloimmunisation incidences per mismatched antigen dose as a measure of immunogenicity.
Findings
Of 54 347 patients assessed, 21 512 were included in our study. Alloantibodies occurred in 474 (2·2%) of all …
学术搜索中的文章
D Evers, RA Middelburg, M de Haas, S Zalpuri… - The Lancet Haematology, 2016