作者
Irene T Lindenburg, Vivianne E Smits-Wintjens, Jeanine M van Klink, Esther Verduin, Inge L van Kamp, Frans J Walther, Henk Schonewille, Ilias I Doxiadis, Humphrey H Kanhai, Jan M van Lith, Erik W van Zwet, Dick Oepkes, Anneke Brand, Enrico Lopriore, LOTUS Study Group
发表日期
2012/2/1
期刊
American journal of obstetrics and gynecology
卷号
206
期号
2
页码范围
141. e1-141. e8
出版商
Mosby
简介
OBJECTIVE
To determine the incidence and risk factors for neurodevelopmental impairment (NDI) in children with hemolytic disease of the fetus/newborn treated with intrauterine transfusion (IUT).
STUDY DESIGN
Neurodevelopmental outcome in children at least 2 years of age was assessed using standardized tests, including the Bayley Scales of Infant Development, the Wechsler Preschool and Primary Scale of Intelligence, and the Wechsler Intelligence Scale for Children, according to the children's age. Primary outcome was the incidence of neurodevelopmental impairment defined as at least one of the following: cerebral palsy, severe developmental delay, bilateral deafness, and/or blindness.
RESULTS
A total of 291 children were evaluated at a median age of 8.2 years (range, 2–17 years). Cerebral palsy was detected in 6 (2.1%) children, severe developmental delay in 9 (3.1%) children, and bilateral …
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