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The route of administration refers to the way in which medication is given and how users administer their drugs of choice. 1 Psychedelics are commonly taken recreationally by oral or respiratory administration, but they can be taken in other ways as well, such as mucosally or intravenously. Understanding how the route of administration changes the effectiveness of a compound is important in the translational value of psychedelic research. Translational research typically means that what is learned through basic science can be translated to what is known clinically.