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For resolving absolute concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy it is necessary to calculate the light scattering and absorption, at multiple wavelengths with some depth resolution. We report a novel methodology that combines multi-distance frequency and broadband spectrometers to quantify chromophores in turbid media by using a spatially resolved algorithm. Preliminary results in a dynamic phantom showed good agreement between measured and theoretical calculated absolute concentrations of known dyes.