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Methods

After informed consent, in 12 ASA II patients with metastatic malignant disease who were eligible for WBH hemodynamic, metabolic parameters, lactate and catecholamine plasma concentrations were studied over a 24 h period. The heating device was a RHS-7500, Enthermics Medical Systems, Inc., Menomonee Falls, WI, USA. Target temperature was 41.8 C, time at target was 60 min. Anaesthesia was total intravenous anaesthesia by TCI using propofol (4-6 µg/kg/min). Patients were intubated and mechanically ventilated with an FiO 2, of 0.4 after induction with sufentanil (0.3-0.4 µg/kg), propofol and rocuronium (0.8 mg/kg). Measurements were taken at baseline, during heating, at plateau, after reaching baseline temperature and at 24 h post plateau. Hemodynamic data consisted of HR, MAP, CVP, PAP, PCWP, CI, SVR. Metabolic data were obtained by indirect calorimetry (Puritan Bennett 7250 …