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Methods. After IRB-approval and written informed consent 8 patients (ASA III) undergoing whole body hyperthermia (WBH) for chemotherapy were investigated. At 4 defined points (P1-4: baseline, 39.5 C, 41.8 C, 38 C) CI, stroke volume index (SVI) and systemic vascular resistance (SVR) were assessed simultaneously by either of the methods, and MAP was recorded. TEE values were calculated via Doppler echocardiography in the LVOT and PCCI via an arterial line in the femoral artery. Thermodilution calibration of the PC-device was performed before P1. Statistics: two way ANOVA for repeated measurements, post-hoc paired t-test (bonferroni-corrected). p*< 0.01= significant

Results. Table 1: PC and DE-derived data.*= p< 0.01 vs. the other method. Although absolute values of CI and SVI were showing a close agreement at P1, significant differences were found between the methods with decreasing SVR and increasing body temperature, while SVR values did not differ significantly. MAP remained stable during the procedure.

Conclusions. Changes in body temperature and/or in systemic vascular resistance seem to influence the pulse contour-analysis measurements. Thus further studies have to show whether this method is valid for continuous monitoring. Meanwhile further calibrations of the PC-device seem to be necessary for accurate assessments.