作者
M Von Seth, L Hillered, A Otterbeck, K Hanslin, A Larsson, J Sjölin, M Lipcsey, ME Cove, NS Chew, LH Vu, RZ Lim, Z Puthucheary, K Hanslin, F Wilske, P Skorup, E Tano, J Sjölin, M Lipcsey, I Derese, S Thiessen, S Derde, T Dufour, L Pauwels, Y Bekhuis, G Van den Berghe, I Vanhorebeek, M Khan, D Dwivedi, J Zhou, A Prat, NG Seidah, PC Liaw, AE Fox-Robichaud, M Von Seth, P Skorup, L Hillered, A Larsson, J Sjölin, M Lipcsey, A Otterbeck, K Hanslin, M Lipcsey, A Larsson, M Von Seth, T Correa, J Pereira, J Takala, S Jakob, P Skorup, L Maudsdotter, E Tano, M Lipcsey, M Castegren, A Larsson, J Sjölin, M Xue, JY Xu, L Liu, YZ Huang, FM Guo, Y Yang, HB Qiu, A Kuzovlev, V Moroz, A Goloubev, A Myazin, A Chumachenko, V Pisarev, N Takeyama, M Tsuda, H Kanou, R Aoki, Y Kajita, M Hashiba, T Terashima, A Tomino, R Davies, KP O’Dea, S Soni, JK Ward, DJ O’Callaghan, M Takata, AC Gordon, J Wilson, Y Zhao, M Singer, J Spencer, M Shankar-Hari, K Roveran Genga, C Lo, MS Cirstea, KR Walley, JA Russell, A Linder, JH Boyd, A Sedlag, C Riedel, M Georgieff, E Barth, H Bracht, A Essig, D Henne-Bruns, F Gebhard, K Orend, M Halatsch, M Weiss, M Chase, E Freinkman, A Uber, X Liu, MN Cocchi, MW Donnino, M Peetermans, L Liesenborghs, J Claes, T Vanassche, M Hoylaerts, M Jacquemin, K Vanhoorelbeke, S De Meyer, P Verhamme, A Vögeli, M Ottiger, M Meier, C Steuer, L Bernasconi, A Huber, M Christ-Crain, C Henzen, C Hoess, R Thomann, W Zimmerli, B Müller, P Schütz, D Hoppensteadt, A Walborn, M Rondina, K Tsuruta, J Fareed, S Tachyla, T Ikeda, S Ono, T Ueno, S Suda, T Nagura, E Damiani, R Domizi, C Scorcella, S Tondi, S Pierantozzi
发表日期
2017/3
期刊
Critical Care
卷号
21
页码范围
1-70
出版商
BioMed Central
简介
Methods
We submitted anesthetized piglets to sepsis (n= 12) or placebo (n= 4) and monitored them for 3 hours. Plasma lactate and markers of organ failure were measured hourly, as was muscle metabolism by microdialysis. Energy consumption was intervened locally by infusing ouabain through one microdialysis catheter to block major energy expenditure of the cells, by inhibiting the major energy consuming enzyme, N+/K+-ATPase. Similarly, energy production was blocked infusing sodium cyanide (NaCN), in a different region, to block the cytochrome oxidase in muscle tissue mitochondria.
Results
All animals submitted to sepsis fulfilled sepsis criteria as defined in Sepsis-3, whereas no animals in the placebo group did. Muscle glucose decreased during sepsis independently of N+/K+-ATPase or cytochrome oxidase blockade. Muscle lactate did not increase during sepsis in naïve metabolism. However, during …
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