作者
Anna Birukov, Branimir Plavša, Fabian Eichelmann, Olga Kuxhaus, Rosangela Akemi Hoshi, Najda Rudman, Tamara Štambuk, Irena Trbojević-Akmačić, Catarina Schiborn, Jakub Morze, Matea Mihelčić, Ana Cindrić, Yanyan Liu, Olga Demler, Markus Perola, Samia Mora, Matthias B Schulze, Gordan Lauc, Clemens Wittenbecher
发表日期
2022/11/1
期刊
Diabetes care
卷号
45
期号
11
页码范围
2729-2736
出版商
American Diabetes Association
简介
OBJECTIVE
N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). We hypothesized that specific IgG N-glycans are associated with incident type 2 diabetes and cardiovascular disease (CVD).
RESEARCH DESIGN AND METHODS
We performed case-cohort studies within the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam cohort (2,127 in the type 2 diabetes subcohort [741 incident cases]; 2,175 in the CVD subcohort [417 myocardial infarction and stroke cases]). Relative abundances of 24 IgG N-glycan peaks (IgG-GPs) were measured by ultraperformance liquid chromatography, and eight glycosylation traits were derived based on structural similarity. End point–associated IgG-GPs were preselected with fractional polynomials, and prospective associations were estimated in confounder-adjusted …
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A Birukov, B Plavša, F Eichelmann, O Kuxhaus… - Diabetes care, 2022