作者
Panayiotis Louca, Tamara Štambuk, Azra Frkatović-Hodžić, Ana Nogal, Massimo Mangino, Sarah E Berry, Helena Deriš, George Hadjigeorgiou, Jonathan Wolf, Martina Vinicki, Paul W Franks, Ana M Valdes, Tim D Spector, Gordan Lauc, Cristina Menni
发表日期
2023/7/3
来源
BMC medicine
卷号
21
期号
1
页码范围
231
出版商
BioMed Central
简介
Background
A dysregulated postprandial metabolic response is a risk factor for chronic diseases, including type 2 diabetes mellitus (T2DM). The plasma protein N-glycome is implicated in both lipid metabolism and T2DM risk. Hence, we first investigate the relationship between the N-glycome and postprandial metabolism and then explore the mediatory role of the plasma N-glycome in the relationship between postprandial lipaemia and T2DM.
Methods
We included 995 individuals from the ZOE-PREDICT 1 study with plasma N-glycans measured by ultra-performance liquid chromatography at fasting and triglyceride, insulin, and glucose levels measured at fasting and following a mixed-meal challenge. Linear mixed models were used to investigate the associations between plasma protein N-glycosylation and metabolic response (fasting, postprandial (Cmax), or change from fasting). A mediation analysis was used …
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P Louca, T Štambuk, A Frkatović-Hodžić, A Nogal… - BMC medicine, 2023