作者
Sodbo Zh Sharapov, Alexandra S Shadrina, Yakov A Tsepilov, Elizaveta E Elgaeva, Evgeny S Tiys, Sofya G Feoktistova, Olga O Zaytseva, Frano Vuckovic, Rafael Cuadrat, Susanne Jäger, Clemens Wittenbecher, Lennart C Karssen, Maria Timofeeva, Therese Tillin, Irena Trbojević-Akmačić, Tamara Štambuk, Najda Rudman, Jasminka Krištić, Jelena Šimunović, Ana Momčilović, Marija Vilaj, Julija Jurić, Anita Slana, Ivan Gudelj, Thomas Klarić, Livia Puljak, Andrea Skelin, Antonia Jeličić Kadić, Jan Van Zundert, Nishi Chaturvedi, Harry Campbell, Malcolm Dunlop, Susan M Farrington, Margaret Doherty, Concetta Dagostino, Christian Gieger, Massimo Allegri, Frances Williams, Matthias B Schulze, Gordan Lauc, Yurii S Aulchenko
发表日期
2021/2
期刊
Glycobiology
卷号
31
期号
2
页码范围
82-88
出版商
Oxford University Press
简介
Human protein glycosylation is a complex process, and its in vivo regulation is poorly understood. Changes in glycosylation patterns are associated with many human diseases and conditions. Understanding the biological determinants of protein glycome provides a basis for future diagnostic and therapeutic applications. Genome-wide association studies (GWAS) allow to study biology via a hypothesis-free search of loci and genetic variants associated with a trait of interest. Sixteen loci were identified by three previous GWAS of human plasma proteome N-glycosylation. However, the possibility that some of these loci are false positives needs to be eliminated by replication studies, which have been limited so far. Here, we use the largest set of samples so far (4802 individuals) to replicate the previously identified loci. For all but one locus, the expected replication power exceeded 95%. Of the 16 loci reported …
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SZ Sharapov, AS Shadrina, YA Tsepilov, EE Elgaeva… - Glycobiology, 2021