作者
Giancarlo Agnelli, Paolo Prandoni, Maria Gabriella Santamaria, Paola Bagatella, Alfonso Iorio, Mario Bazzan, Marco Moia, Giuliana Guazzaloca, Adriano Bertoldi, Cristina Tomasi, Gianluigi Scannapieco, Alessandra Ascani, Sabina Villalta, Michela Frulla, Laura Mosena, Antonio Girolami, Antonella Vaccarino, Adriano Alatri, Gualtiero Palareti, Mario Marchesi, Giovanni Battista Ambrosio, Roberto Parisi, Silvia Doria, Luigi Steidl, Fabio Ambrosini, Mauro Silingardi, Angelo Ghirarduzzi, Ido Iori, Walter Ageno, Warfarin Optimal Duration Italian Trial Investigators
发表日期
2001/7/19
期刊
New England Journal of Medicine
卷号
345
期号
3
页码范围
165-169
出版商
Massachusetts Medical Society
简介
Background
In patients with idiopathic deep venous thrombosis, continuing anticoagulant therapy beyond three months is associated with a reduced incidence of recurrent thrombosis during the period of therapy. Whether this benefit persists after anticoagulant therapy is discontinued is controversial.
Methods
Patients with a first episode of idiopathic proximal deep venous thrombosis who had completed three months of oral anticoagulant therapy were randomly assigned to the discontinuation of oral anticoagulants or to their continuation for nine additional months. The primary study outcome was recurrence of symptomatic, objectively confirmed venous thromboembolism during at least two years of follow-up.
Results
The primary intention-to-treat analysis showed that of 134 patients assigned to continued oral anticoagulant therapy, 21 had a recurrence of venous thromboembolism (15.7 percent; average follow …
引用总数
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G Agnelli, P Prandoni, MG Santamaria, P Bagatella… - New England Journal of Medicine, 2001