作者
Siyuan Zheng, Andrew D Cherniack, Ninad Dewal, Richard A Moffitt, Ludmila Danilova, Bradley A Murray, Antonio M Lerario, Tobias Else, Theo A Knijnenburg, Giovanni Ciriello, Seungchan Kim, Guillaume Assie, Olena Morozova, Rehan Akbani, Juliann Shih, Katherine A Hoadley, Toni K Choueiri, Jens Waldmann, Ozgur Mete, A Gordon Robertson, Hsin-Ta Wu, Benjamin J Raphael, Lina Shao, Matthew Meyerson, Michael J Demeure, Felix Beuschlein, Anthony J Gill, Stan B Sidhu, Madson Q Almeida, Maria CBV Fragoso, Leslie M Cope, Electron Kebebew, Mouhammed A Habra, Timothy G Whitsett, Kimberly J Bussey, William E Rainey, Sylvia L Asa, Jérôme Bertherat, Martin Fassnacht, David A Wheeler, Roel GW Verhaak, Thomas J Giordano, Gary D Hammer, Guillaume Assié, Hsin-Tu Wu, Madson Almeida, Maria Candida Barisson Fragoso, Mouhammed Amir Habra, Christopher Benz, Adrian Ally, Miruna Balasundaram, Reanne Bowlby, Denise Brooks, Yaron SN Butterfield, Rebecca Carlsen, Noreen Dhalla, Ranabir Guin, Robert A Holt, Steven JM Jones, Katayoon Kasaian, Darlene Lee, Haiyan I Li, Lynette Lim, Yussanne Ma, Marco A Marra, Michael Mayo, Richard A Moore, Andrew J Mungall, Karen Mungall, Sara Sadeghi, Jacqueline E Schein, Payal Sipahimalani, Angela Tam, Nina Thiessen, Peter J Park, Matthias Kroiss, Jianjiong Gao, Chris Sander, Nikolaus Schultz, Corbin D Jones, Raju Kucherlapati, Piotr A Mieczkowski, Joel S Parker, Charles M Perou, Donghui Tan, Umadevi Veluvolu, Matthew D Wilkerson, D Neil Hayes, Marc Ladanyi, Marcus Quinkler, J Todd Auman, Ana Claudia Latronico, Berenice B Mendonca, Mathilde Sibony, Zack Sanborn, Michelle Bellair, Christian Buhay, Kyle Covington, Mahmoud Dahdouli, Huyen Dinh, Harsha Doddapaneni, Brittany Downs, Jennifer Drummond, Richard Gibbs, Walker Hale, Yi Han, Alicia Hawes, Jianhong Hu, Nipun Kakkar, Divya Kalra, Ziad Khan, Christine Kovar, Sandy Lee, Lora Lewis, Margaret Morgan, Donna Morton, Donna Muzny, Jireh Santibanez, Liu Xi, Bertrand Dousset, Lionel Groussin, Rossella Libé, Lynda Chin, Sheila Reynolds, Ilya Shmulevich, Sudha Chudamani, Jia Liu, Laxmi Lolla, Ye Wu, Jen Jen Yeh, Saianand Balu, Tom Bodenheimer, Alan P Hoyle, Stuart R Jefferys, Shaowu Meng, Lisle E Mose, Yan Shi, Janae V Simons, Matthew G Soloway, Junyuan Wu, Wei Zhang, Kenna R Mills Shaw, John A Demchok, Ina Felau, Margi Sheth, Roy Tarnuzzer, Zhining Wang, Liming Yang, Jean C Zenklusen, Jiashan Julia Zhang
发表日期
2016/5/9
期刊
Cancer cell
卷号
29
期号
5
页码范围
723-736
出版商
Elsevier
简介
We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.
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