作者
Tamara G Fong, Sarinnapha M Vasunilashorn, Long Ngo, Towia A Libermann, Simon T Dillon, Eva M Schmitt, Alvaro Pascual‐Leone, Steven E Arnold, Richard N Jones, Edward R Marcantonio, Sharon K Inouye, SAGES Study Group
发表日期
2020/11
期刊
Annals of neurology
卷号
88
期号
5
页码范围
984-994
出版商
John Wiley & Sons, Inc.
简介
Objective
To examine the association of the plasma neuroaxonal injury markers neurofilament light (NfL), total tau, glial fibrillary acid protein, and ubiquitin carboxyl‐terminal hydrolase L1 with delirium, delirium severity, and cognitive performance.
Methods
Delirium case–no delirium control (n = 108) pairs were matched by age, sex, surgery type, cognition, and vascular comorbidities. Biomarkers were measured in plasma collected preoperatively (PREOP), and 2 days (POD2) and 30 days postoperatively (PO1MO) using Simoa technology (Quanterix, Lexington, MA). The Confusion Assessment Method (CAM) and CAM‐S (Severity) were used to measure delirium and delirium severity, respectively. Cognitive function was measured with General Cognitive Performance (GCP) scores.
Results
Delirium cases had higher NfL on POD2 and PO1MO (median matched pair difference = 16.2pg/ml and 13.6pg/ml …
学术搜索中的文章
TG Fong, SM Vasunilashorn, L Ngo, TA Libermann… - Annals of neurology, 2020