作者
Joyce M Ngoi, Peter K Quashie, Collins M Morang'a, Joseph HK Bonney, Dominic SY Amuzu, Selassie Kumordjie, Ivy A Asante, Evelyn Y Bonney, Miriam Eshun, Linda Boatemaa, Vanessa Magnusen, Erasmus N Kotey, Nicaise T Ndam, Frederick Tei-Maya, Augustina K Arjarquah, Evangeline Obodai, Isaac D Otchere, Yaw Bediako, Joe K Mutungi, Lucas N Amenga-Etego, John K Odoom, Abraham K Anang, George B Kyei, Bright Adu, William K Ampofo, Gordon A Awandare
发表日期
2021/4
期刊
Experimental Biology and Medicine
卷号
246
期号
8
页码范围
960-970
出版商
SAGE Publications
简介
The confirmed case fatality rate for the coronavirus disease 2019 (COVID-19) in Ghana has dropped from a peak of 2% in March to be consistently below 1% since May 2020. Globally, case fatality rates have been linked to the strains/clades of circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within a specific country. Here we present 46 whole genomes of SARS-CoV-2 circulating in Ghana, from two separate sequencing batches: 15 isolates from the early epidemic (March 12–April 1 2020) and 31 from later time-points ( 25–27 May 2020). Sequencing was carried out on an Illumina MiSeq system following an amplicon-based enrichment for SARS-CoV-2 cDNA. After genome assembly and quality control processes, phylogenetic analysis showed that the first batch of 15 genomes clustered into five clades: 19A, 19B, 20A, 20B, and 20C, whereas the second batch of 31 genomes clustered to …
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JM Ngoi, PK Quashie, CM Morang'a, JHK Bonney… - Experimental Biology and Medicine, 2021
