作者
Manar M Elhassan, Dalton L Glasco, Anjaiah Sheelam, Amr M Mahmoud, Maha A Hegazy, Shereen Mowaka, Jeffrey G Bell
发表日期
2024/3/15
期刊
Biosensors and Bioelectronics
卷号
248
页码范围
115971
出版商
Elsevier
简介
Apomorphine is a dopamine agonist that is used for the management of Parkinson's disease and has been proven to effectively decrease the off-time duration, where the symptoms recur, in Parkinson's disease patients. This paper describes the design and fabrication of the first potentiometric sensor for the determination of apomorphine in bulk and human plasma samples. The fabrication protocol involves stereolithographic 3D printing, which is a unique tool for the rapid fabrication of low-cost sensors. The solid-contact apomorphine ion-selective electrode combines a carbon-mesh/thermoplastic composite as the ion-to-electron transducer and a 3D printed ion-selective membrane, doped with the ionophore calix[6]arene. The sensor selectively measures apomorphine in the presence of other biologically present cations – sodium, potassium, magnesium, and calcium – as well as the commonly prescribed …
学术搜索中的文章
MM Elhassan, DL Glasco, A Sheelam, AM Mahmoud… - Biosensors and Bioelectronics, 2024