作者
Otávio Melo Espíndola, Carlos Otávio Brandão, Yago Côrtes Pinheiro Gomes, Marilda Siqueira, Cristiane Nascimento Soares, Marco Antônio Sales Dantas Lima, Ana Claudia Celestino Bezerra Leite, Guilherme Torezani, Abelardo Queiroz Campos Araujo, Marcus Tulius Teixeira Silva
发表日期
2021/1/1
期刊
International Journal of Infectious Diseases
卷号
102
页码范围
155-162
出版商
Elsevier
简介
Objectives
To analyze the cerebrospinal fluid (CSF) of patients with SARS-CoV-2 infection and neurological manifestations to provide evidence for the understanding of mechanisms associated with central nervous system (CNS) involvement in COVID-19.
Methods
Patients (n = 58) were grouped according to their main neurological presentation: headache (n = 14); encephalopathy (n = 24); inflammatory neurological diseases, including meningoencephalitis (n = 4), acute myelitis (n = 3), meningitis (n = 2), acute disseminated encephalomyelitis (ADEM) (n = 2), encephalitis (n = 2), and neuromyelitis optica (n = 1); and Guillain-Barré syndrome (n = 6). Data about age, sex, cerebrovascular disease, and intracranial pressure were evaluated in combination with CSF profiles defined by cell counts, total protein and glucose levels, concentration of total Tau and neurofilament light chain (NfL) proteins …
学术搜索中的文章
OM Espíndola, CO Brandão, YCP Gomes, M Siqueira… - International Journal of Infectious Diseases, 2021