作者
Mattias Mandorfer, Karin Kozbial, Philipp Schwabl, David Chromy, Georg Semmler, Albert F Stättermayer, Matthias Pinter, Virginia Hernández‐Gea, Monika Fritzer‐Szekeres, Petra Steindl‐Munda, Michael Trauner, Markus Peck‐Radosavljevic, Juan C García‐Pagán, Peter Ferenci, Thomas Reiberger
发表日期
2020/3
期刊
Hepatology
卷号
71
期号
3
页码范围
1023-1036
简介
Background and Aims
Sustained virologic response (SVR) to interferon (IFN)‐free therapies ameliorates portal hypertension (PH); however, it remains unclear whether a decrease in hepatic venous pressure gradient (HVPG) after cure of hepatitis C translates into a clinical benefit. We assessed the impact of pretreatment HVPG, changes in HVPG, and posttreatment HVPG on the development of hepatic decompensation in patients with PH who achieved SVR to IFN‐free therapy. Moreover, we evaluated transient elastography (TE) and von Willebrand factor to platelet count ratio (VITRO) as noninvasive methods for monitoring the evolution of PH.
Approach and Results
The study comprised 90 patients with HVPG ≥ 6 mm Hg who underwent paired HVPG, TE, and VITRO assessments before (baseline [BL]) and after (follow‐up [FU]) IFN‐free therapy. FU HVPG but not BL HVPG predicted hepatic decompensation …
学术搜索中的文章
M Mandorfer, K Kozbial, P Schwabl, D Chromy… - Hepatology, 2020