作者
Lorenz Balcar, Benedikt Simbrunner, Rafael Paternostro, Mathias Jachs, Lukas Hartl, Georg Semmler, Benedikt Silvester Hofer, Albert Friedrich Stättermayer, Matthias Pinter, Ton Lisman, Michael Trauner, Peter Quehenberger, Thomas Reiberger, Bernhard Scheiner, Mattias Mandorfer
发表日期
2024/1/1
期刊
JHEP Reports
卷号
6
期号
1
页码范围
100934
出版商
Elsevier
简介
Background & Aims
Increased aggregation of individual platelets upon activation, as assessed by whole blood aggregometry standardised to platelet count (PLT), has recently been linked to progression of advanced chronic liver disease (ACLD). Moreover, changes in primary haemostasis have been implicated in bleeding and thrombosis in patients with ACLD.
We aimed (i) to identify the determinants of the primary haemostatic capacity – as assessed by Platelet Function Analyzer 100 (PFA-100) (‘in vitro bleeding time’) – in patients with ACLD and (ii) to investigate its potential association with clinical outcomes.
Methods
PFA-100 was performed in 688 patients with ACLD undergoing hepatic venous pressure gradient measurement. Hepatic decompensation and liver-related death as well as bleeding and thrombosis were the outcomes of interest.
Results
Sixty-three percent of patients had a PFA-100 collagen …
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L Balcar, B Simbrunner, R Paternostro, M Jachs, L Hartl… - JHEP Reports, 2024
