作者
Michael C Peters, Satria Sajuthi, Peter Deford, Stephanie Christenson, Cydney L Rios, Michael T Montgomery, Prescott G Woodruff, David T Mauger, Serpil C Erzurum, Mats W Johansson, Loren C Denlinger, Nizar N Jarjour, Mario Castro, Annette T Hastie, Wendy Moore, Victor E Ortega, Eugene R Bleecker, Sally E Wenzel, Elliot Israel, Bruce D Levy, Max A Seibold, John V Fahy
发表日期
2020/7/1
期刊
American journal of respiratory and critical care medicine
卷号
202
期号
1
页码范围
83-90
出版商
American Thoracic Society
简介
Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (transmembrane protease serine 2) mediate viral infection of host cells. We reasoned that differences in ACE2 or TMPRSS2 gene expression in sputum cells among patients with asthma may identify subgroups at risk for COVID-19 morbidity.
Objectives: To determine the relationship between demographic features and sputum ACE2 and TMPRSS2 gene expression in asthma.
Methods: We analyzed gene expression for ACE2 and TMPRSS2, and for ICAM-1 (intercellular adhesion molecule 1) (rhinovirus receptor as a comparator) in sputum cells from 330 participants in SARP-3 (Severe Asthma Research Program-3) and 32 healthy control subjects.
Measurements and Main Results: Gene expression of ACE2 was lower than TMPRSS2 …
学术搜索中的文章
MC Peters, S Sajuthi, P Deford, S Christenson, CL Rios… - American journal of respiratory and critical care …, 2020
MC Peters, JV Fahy - American Journal of Respiratory and Critical Care …, 2020
MC Peters, S Sajuthi, P Deford, S Christenson, CL Rios… - Am J Respir Crit Care Med, 2020
MC Peters, JV Fahy, LC Denlinger - American Journal of Respiratory and Critical Care …, 2020