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Melanin is synthesized in the human epidermis within melanocytes and transferred to keratinocytes to regulate skin colour, where it provides protection against ultraviolet radiation (UVR)-induced damage. The Fitzpatrick scale stratifies our skin’s tanning response to UVR into six skin phototypes (SPT), SPT-I lightest to SPT-VI darkest. This study investigated the impact of UVR and visible light stimulation on Caucasian skin ex vivo. We treated skin obtained from SPT-I,-II and-III healthy donors with one daily doses of 6 J/cm 2 (UVR) and 140 J/cm 2 (blue or green light) for a period of three days, and assessed their influence on observable surface tanning response, histological melanin content, DNA damage, and cell apoptosis. UVR, blue and green light all stimulated a tanning response in SPT-II and-III, but none of these wavelengths of light induced a tanning response in SPT-I. Using Warthin-Starry (WTS), we …