作者
Michelle MY Chan, Rajalakshmi Santhanakrishnan, Jenny PC Chong, Zhaojin Chen, Bee Choo Tai, Oi Wah Liew, Tze Pin Ng, Lieng H Ling, David Sim, Kui Toh G Leong, Poh Shuan Daniel Yeo, Hean‐Yee Ong, Fazlur Jaufeerally, Raymond Ching‐Chiew Wong, Ping Chai, Adrian F Low, Arthur M Richards, Carolyn SP Lam
发表日期
2016/1
期刊
European journal of heart failure
卷号
18
期号
1
页码范围
81-88
出版商
John Wiley & Sons, Ltd
简介
Aim
Growth differentiation factor 15 (GDF15) is a cytokine highly expressed in states of inflammatory stress. We aimed to study the clinical correlates and prognostic significance of plasma GDF15 in heart failure with preserved ejection fraction (HFpEF) vs. reduced ejection fraction(HFrEF), compared with N‐terminal pro‐brain natriuretic peptide (NT‐proBNP), an indicator of haemodynamic wall stress.
Methods
Plasma GDF15 and NT‐proBNP were prospectively measured in 916 consecutive patients with HFrEF (EF <50%; n = 730) and HFpEF (EF ≥50%; n = 186), and measured again at 6 months in 488 patients. Patients were followed up for a composite outcome of death or first HF rehospitalization.
Results
Median GDF15baseline values were similarly elevated in HFpEF [2862 (1812 represent the 25th percentile and 4176 represent the 75th percentile) ng/L] and HFrEF [2517 (1555, 4030) ng/L] (P = 0 …
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MMY Chan, R Santhanakrishnan, JPC Chong, Z Chen… - European journal of heart failure, 2016