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Coronavirus disease 2019 (COVID-19) has been the most recent disease, with millions of deaths worldwide. Fortunately, vaccines have been developed to immunize the population. However, the distribution of the vaccine is also a significant challenge. Generally, each country defines its strategy to bring it closer to the target population, considering the adequate transport for their conservation, depending on the type of vaccines defined. In this work, a mathematical model is proposed for the distribution of different COVID-19 vaccines in Mexico. Our results suggest an efficient strategy to meet demand in a given period.