作者
Jerry H Brown, Theodore S Jardetzky, Joan C Gorga, Lawrence J Stern, Robert G Urban, Jack L Strominger, Don C Wiley
发表日期
1993/7/1
期刊
Nature
卷号
364
期号
6432
页码范围
33-39
出版商
Nature Publishing Group UK
简介
The three-dimensional structure of the class II histocompatibility glycoprotein HLA-DR1 from human B-cell membranes has been determined by X-ray crystallography and is similar to that of class I HLA. Peptides are bound in an extended conformation that projects from both ends of an 'open-ended' antigen-binding groove. A prominent non-polar pocket into which an 'anchoring' peptide side chain fits is near one end of the binding groove. A dimer of the class II αβ heterodimers is seen in the crystal forms of HLA-DR1, suggesting class II HLA dimerization as a mechanism for initiating the cytoplasmic signalling events in T-cell activation.
引用总数
学术搜索中的文章
JH Brown, TS Jardetzky, JC Gorga, LJ Stern, RG Urban… - Nature, 1993