作者
Luisa Salazar-Vizcaya, Roger D Kouyos, Karin J Metzner, Kamila Caraballo Cortes, Jürg Böni, Cyril Shah, Jan Fehr, Dominique L Braun, Enos Bernasconi, Herbert A Mbunkah, Matthias Hoffmann, Niklaus Labhardt, Matthias Cavassini, Mathieu Rougemont, Huldrych F Günthard, Olivia Keiser, Andri Rauch
发表日期
2019/6/5
期刊
The Journal of infectious diseases
卷号
220
期号
1
页码范围
91-99
出版商
Oxford University Press
简介
Background
Scale-up of direct-acting antiviral therapy is expected to abate hepatitis C virus (HCV) incidence among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). International transmission could influence this process. We classified HCV infections in HIV-positive MSM as either domestically or internationally acquired, and estimated how this classification changed over time.
Methods
HCV subtype 1a (the most frequent subtype among MSM) genomes from 99 persons enrolled in the Swiss HIV Cohort Study and diagnosed with replicating HCV infections, were sequenced. Sixty-six of these sequences were from MSM. We inferred maximum-likelihood phylogenetic trees and time trees containing a fragment of the NS5B region of these and 374 circulating strains. We inferred transmission clusters from these trees and used the country …
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L Salazar-Vizcaya, RD Kouyos, KJ Metzner… - The Journal of infectious diseases, 2019
