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Objective

There have been conflicting reports on the relationship between gonadotropin stimulation length and embryonic aneuploidy. We hypothesized that a prolonged stimulation could lead to an increase in meiotic and mitotic oocyte errors. This study aims to evaluate the relationship between length of gonadotropin stimulation for in vitro fertilization (IVF) and embryonic aneuploidy of maternal origin.

Materials and Methods

Institutional Review Board approval was obtained. All IVF cycles utilizing preimplantation genetic testing for aneuploidy between 1/2015 and 1/2020 were reviewed. Genotyping was performed using Illumina Cyto12 single nucleotide polymorphism (SNP) microarrays and embryo samples were compared to parental samples across multiple SNP loci to allow to determine the parental origin of each chromosome. Maternal aneuploidy rate was the number of embryos with aneuploidy of maternal or …