作者
Hunna J Watson, Zeynep Yilmaz, Laura M Thornton, Christopher Hübel, Jonathan RI Coleman, Héléna A Gaspar, Julien Bryois, Anke Hinney, Virpi M Leppä, Manuel Mattheisen, Sarah E Medland, Stephan Ripke, Shuyang Yao, Paola Giusti-Rodríguez, Anorexia Nervosa Genetics Initiative, Ken B Hanscombe, Kirstin L Purves, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Roger AH Adan, Lars Alfredsson, Tetsuya Ando, Ole A Andreassen, Jessica H Baker, Wade H Berrettini, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Matteo Cassina, Sven Cichon, Maurizio Clementi, Roger D Cone, Philippe Courtet, Scott Crow, James J Crowley, Unna N Danner, Oliver SP Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E DeSocio, Danielle M Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo, Laramie E Duncan, Karin Egberts, Stefan Ehrlich, Geòrgia Escaramís, Tõnu Esko, Xavier Estivill, Anne Farmer, Angela Favaro, Fernando Fernández-Aranda, Manfred M Fichter, Krista Fischer, Manuel Föcker, Lenka Foretova, Andreas J Forstner, Monica Forzan, Christopher S Franklin, Steven Gallinger, Ina Giegling, Johanna Giuranna, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Sébastien Guillaume, Yiran Guo, Hakon Hakonarson, Konstantinos Hatzikotoulas, Joanna Hauser, Johannes Hebebrand, Sietske G Helder, Stefan Herms, Beate Herpertz-Dahlmann, Wolfgang Herzog, Laura M Huckins, James I Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimir Janout, Susana Jiménez-Murcia, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Jaakko Kaprio, Leila Karhunen, Andreas Karwautz, Martien JH Kas, James L Kennedy, Anna Keski-Rahkonen, Kirsty Kiezebrink, Youl-Ri Kim, Lars Klareskog, Kelly L Klump, Gun Peggy S Knudsen, Maria C La Via, Stephanie Le Hellard, Robert D Levitan, Dong Li, Lisa Lilenfeld, Bochao Danae Lin, Jolanta Lissowska, Jurjen Luykx, Pierre J Magistretti, Mario Maj, Katrin Mannik, Sara Marsal, Christian R Marshall, Morten Mattingsdal, Sara McDevitt, Peter McGuffin, Andres Metspalu, Ingrid Meulenbelt, Nadia Micali, Karen Mitchell, Alessio Maria Monteleone, Palmiero Monteleone, Melissa A Munn-Chernoff, Benedetta Nacmias, Marie Navratilova, Ioanna Ntalla, Julie K O’Toole, Roel A Ophoff, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papezova, Dalila Pinto, Raquel Rabionet, Anu Raevuori, Nicolas Ramoz, Ted Reichborn-Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Alessandro Rotondo, Dan Rujescu, Filip Rybakowski, Paolo Santonastaso, André Scherag, Stephen W Scherer, Ulrike Schmidt, Nicholas J Schork, Alexandra Schosser, Jochen Seitz
发表日期
2019/8
期刊
Nature genetics
卷号
51
期号
8
页码范围
1207-1214
出版商
Nature Publishing Group US
简介
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness, affecting 0.9–4% of women and 0.3% of men–, with twin-based heritability estimates of 50–60%. Mortality rates are higher than those in other psychiatric disorders, and outcomes are unacceptably poor. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI), and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index …
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HJ Watson, Z Yilmaz, LM Thornton, C Hübel… - Nature genetics, 2019