作者
Sonia Moreno‐Grau, Itziar De Rojas, Isabel Hernández, Inés Quintela, Laura Montrreal, Montserrat Alegret, Begoña Hernández‐Olasagarre, Laura Madrid, Antonio González‐Perez, Olalla Maroñas, Maitée Rosende‐Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Carla Abdelnour, Octavio Rodríguez‐Gómez, Silvia Gil, Miguel Ángel Santos‐Santos, Ana Espinosa, Gemma Ortega, Ángela Sanabria, Alba Pérez‐Cordón, Pilar Cañabate, Mariola Moreno, Silvia Preckler, Susana Ruiz, Nuria Aguilera, Juan Antonio Pineda, Juan Macías, Emilio Alarcón‐Martín, Oscar Sotolongo‐Grau, GR@ ACE consortium, C Abdelnour, N Aguilera, E Alarcon, M Alegret, A Benaque, M Boada, M Buendia, P Cañabate, A Carracedo, A Corbatón, I de Rojas, S Diego, A Espinosa, A Gailhajenet, P García González, S Gil, M Guitart, A González Pérez, I Hernández, M Ibarria, A Lafuente, J Macias, O Maroñas, E Martín, MT Martínez, M Marquié, A Mauleón, G Monté‐Rubio, L Montrreal, S Moreno‐Grau, M Moreno, A Orellana, G Ortega, A Pancho, E Pelejà, A Pérez‐Cordon, JA Pineda, S Preckler, I Quintela, LM Real, O Rodríguez‐Gómez, M Rosende‐Roca, A Ruiz, S Ruiz, ME Sáez, A Sanabria, MA Santos‐Santos, M Serrano‐Rios, O Sotolongo‐Grau, L Tárraga, S Valero, L Vargas, DEGESCO consortium, AD Adarmes‐Gómez, E Alarcón‐Martín, I Álvarez, V Álvarez, Goo Amer‐Ferrer, M Antequera, C Antúnez, M Baquero, M Bernal, R Blesa, M Boada, D Buiza‐Rueda, MJ Bullido, JA Burguera, M Calero, F Carrillo, M Carrión‐Claro, MJ Casajeros, J Clarimón, JM Cruz‐Gamero, MM de Pancorbo, I de Rojas, T del Ser, M Diez‐Fairen, J Fortea, E Franco, A Frank‐García, JM García‐Alberca, S Garcia Madrona, G Garcia‐Ribas, P Gómez‐Garre, I Hernández, S Hevilla, S Jesús, Labrador Espinosa, C Lage, A Legaz, A Lleó, A López de Munáin, S López‐García, D Macias, S Manzanares, M Marín, J Marín‐Muñoz, T Marín, M Marquié, A Martín Montes, B Martínez, C Martínez, V Martínez, P Martínez‐Lage Álvarez, M Medina, M Mendioroz Iriarte, M Menéndez‐González, P Mir, JL Molinuevo, G Monté‐Rubio, L Montrreal, S Moreno‐Grau, A Orellana, AB Pastor, P Pastor, J Pérez Tur, T Periñán‐Tocino, G Piñol Ripoll
发表日期
2019/10
期刊
Alzheimer's & Dementia
卷号
15
期号
10
页码范围
1333-1347
出版商
The Alzheimer's Association
简介
Introduction
Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways.
Methods
Genome Research at Fundacio ACE (GR@ACE) is a genome‐wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta‐analyzed with additional genome‐wide association study data sets.
Results
We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta‐analysis strategy …
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S Moreno‐Grau, I De Rojas, I Hernández, I Quintela… - Alzheimer's & Dementia, 2019