作者
James A King, Jocelyn Jeong, Fox E Underwood, Joshua Quan, Nicola Panaccione, Joseph W Windsor, Stephanie Coward, Jennifer Debruyn, Paul E Ronksley, Abdel-Aziz Shaheen, Hude Quan, Jenny Godley, Sander Veldhuyzen van Zanten, Benjamin Lebwohl, Siew C Ng, Jonas F Ludvigsson, Gilaad G Kaplan
发表日期
2020/4/1
来源
Official journal of the American College of Gastroenterology| ACG
卷号
115
期号
4
页码范围
507-525
出版商
LWW
简介
OBJECTIVES:
To conduct a systematic review and meta-analysis that defines the worldwide incidence of celiac disease (CD) and examines temporal trends.
METHODS:
MEDLINE and EMBASE were searched for population-based studies reporting the incidence of CD in the overall population, children, or adults. No limits were placed on year or language of publication. Studies solely examining at-risk populations (eg, patients with type 1 diabetes) were excluded. Random-effects models were performed to meta-analyze sex-and age-specific incidence in the 21st century. Temporal trend analyses assessed the average annual percent change in CD incidence over time.
RESULTS:
Of 11,189 citations, 86 eligible studies were identified for inclusion, of which 50 were deemed suitable for analyses. In the 21st century, the pooled female incidence of CD was 17.4 (95% confidence interval [CI]: 13.7, 21.1)(I 2= 99.5%) per …
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