作者
Peter Stenvinkel, Alicia Marchlewska, Roberto Pecoits-Filho, Olof Heimbürger, Zhengzhong Zhang, Catherine Hoff, Cliff Holmes, Jonas Axelsson, Sivonne Arvidsson, Martin Schalling, Peter Barany, Bengt Lindholm, Louise Nordfors
发表日期
2004/1/1
期刊
Kidney international
卷号
65
期号
1
页码范围
274-281
出版商
Elsevier
简介
Adiponectin in renal disease: Relationship to phenotype and genetic variation in the gene encoding adiponectin.
Background
The prevalence of cardiovascular disease (CVD) and inflammation is high in patients with end-stage renal disease (ESRD). Adiponectin is an adipocytokine that may have significant anti-inflammatory and anti-atherosclerotic effects. Low adiponectin levels have previously been found in patients with high risk for CVD.
Methods
In a cohort of 204 (62% males) ESRD patients aged 52 ± 1 years the following parameters were studied: presence of CVD, body composition, plasma adiponectin (N = 107), cholesterol, triglycerides, HDL-cholesterol, serum leptin, high-sensitivity C-reactive protein (hs-CRP), urinary albumin excretion (UAE), and single-nucleotide polymorphisms (SNPs) in the apM1 gene at positions –11391, –11377, 45, and 276. Thirty-six age- (52 ± 2 years) and gender-matched (64 …
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P Stenvinkel, A Marchlewska, R Pecoits-Filho… - Kidney international, 2004