作者
Gaalle Gillerot, Eric Goffin, Catherine Michel, Pieter Evenepoel, Wim Van Biesen, Michel Tintillier, Peter Stenvinkel, Olof Heimbarger, Bengt Lindholm, Louise Nordfors, Annie Robert, Olivier Devuyst
发表日期
2005/6/1
期刊
Kidney international
卷号
67
期号
6
页码范围
2477-2487
出版商
Elsevier
简介
Genetic and clinical factors influence the baseline permeability of the peritoneal membrane.
Background
Patients starting peritoneal dialysis (PD) show a significant variability in small solute transport across the peritoneal membrane (PM). The latter parameter determines dialysis prescription and survival. Clinical factors probably influence solute transport across the PM, but the putative role of genetic variants is unknown.
Methods
We have investigated the influence of functional polymorphisms of VEGF, ENOS, and IL-6, together with clinical and biological factors, on baseline peritoneal equilibration test (PET) parameters in a homogeneous population of 152 unrelated Caucasian PD patients from Belgium and the North of France.
Results
The distribution of the 21 alleles (7 polymorphisms) and linkage disequilibrium parameters were similar in PD patients and healthy subjects. Univariate and multivariate analyses …
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G Gillerot, E Goffin, C Michel, P Evenepoel… - Kidney international, 2005