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Reduced gene expression of adiponectin in fat tissue from patients with end-stage renal disease.

Cardiovascular disease (CVD) is the main cause of death in end-stage renal disease (ESRD) patients. It has been suggested that inflammation plays a key role in the development of both atherosclerosis and malnutrition (MIA), a combination of complications associated with poor outcome. Although plasma levels of adiponectin, a recently discovered anti-inflammatory and antiatherogenic adipocytokine, are markedly elevated in ESRD, gene expression of adiponectin (ApM1) has not been analyzed in ESRD patients.

We analyzed the ApM1 gene expression in adipose tissue from 18 ESRD patients of whom 9 (7 males, 60 ± 8 years, BMI 24 ± 6 kg/m²) had a high prevalence of MIA complications, and 9 age- (55 ± 9 years), gender- (7 males) and BMI- (24 ± 2 kg/m²) matched ESRD patients had few …