作者
Peter Stenvinkel, Kai Wang, Abdul Rashid Qureshi, Jonas Axelsson, Roberto Pecoits-Filho, Ping Gao, Peter Barany, Bengt Lindholm, Tomas Jogestrand, Olof Heimberger, Clifford Holmes, Martin Schalling, Louise Nordfors
发表日期
2005/6/1
期刊
Kidney international
卷号
67
期号
6
页码范围
2383-2392
出版商
Elsevier
简介
Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin.
Background
Vascular calcification is common among end-stage renal disease (ESRD) patients and a central characteristic of the atherosclerotic cardiovascular disease observed in dialysis patients. Fetuin-A, a circulating calcium-regulatory glycoprotein that inhibits vascular calcification, is associated with inflammation and outcome in dialysis patients. In the present study, we evaluated the association between fetuin-A, clinical phenotype, and outcome, as well as the impact of fetuin gene (AHSG) polymorphisms on the protein product and outcome.
Methods
In a cohort of 258 (161 males) ESRD patients starting renal replacement therapy [glomerular filtration rate (GFR) 6.8 ± 0.2 mL/min] aged 52 ± 1 years the following parameters were studied: presence of malnutrition (subjective global assessment …
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P Stenvinkel, K Wang, AR Qureshi, J Axelsson… - Kidney international, 2005