作者
Richard L Prince, Nicole Austin, Amanda Devine, Ian M Dick, David Bruce, Kun Zhu
发表日期
2008/1/14
期刊
Archives of internal medicine
卷号
168
期号
1
页码范围
103-108
出版商
American Medical Association
简介
Background
Ergocalciferol (vitamin D2) supplementation plays a role in fall prevention, but the effect in patients living in the community in sunny climates remains uncertain. We evaluated the effect of ergocalciferol and calcium citrate supplementation compared with calcium alone on the risk of falls in older women at high risk of falling.
Methods
A 1-year population-based, double-blind, randomized controlled trial of 302 community-dwelling ambulant older women aged 70 to 90 years living in Perth, Australia (latitude, 32°S), with a serum 25-hydroxyvitamin D concentration of less than 24.0 ng/mL and a history of falling in the previous year. Participants were randomized to receive ergocalciferol, 1000 IU/d, or identical placebo (hereinafter, ergocalciferol and control groups, respectively). Both groups received calcium citrate, 1000 mg/d. Fall data were collected every 6 weeks.
Results
Ergocalciferol therapy reduced the …
引用总数
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RL Prince, N Austin, A Devine, IM Dick, D Bruce, K Zhu - Archives of internal medicine, 2008