查看文章

OBJECTIVES: To evaluate the effects of vitamin D treatment on muscle strength and mobility in older women with vitamin D insufficiency.

DESIGN: One‐year population‐based, double‐blind, randomized, controlled trial.

SETTING: Perth, Australia (latitude 32°S).

PARTICIPANTS: Three hundred two community‐dwelling ambulant elderly women aged 70 to 90 with a serum 25‐hydroxyvitamin D (25(OH)D) concentration less than 24 ng/mL.

INTERVENTION: Vitamin D₂ 1,000 IU/d or identical placebo; calcium citrate (1 g calcium/d) in both groups.

MEASUREMENTS: Lower limb muscle strength and mobility as assessed using the Timed Up and Go Test (TUAG).

RESULTS: At baseline, mean±standard deviation serum 25(OH)D was 17.7±4.2 ng/mL; this increased to 24.0±5.6 ng/mL in the vitamin D group after 1 year but remained the same in the placebo group. For hip extensor and adductor strength and TUAG …