作者
Nete Tofte, Morten Lindhardt, Katarina Adamova, Stephan JL Bakker, Joachim Beige, Joline WJ Beulens, Andreas L Birkenfeld, Gemma Currie, Christian Delles, Ingo Dimos, Lidmila Francová, Marie Frimodt-Møller, Peter Girman, Rüdiger Göke, Tereza Havrdova, Hiddo JL Heerspink, Adriaan Kooy, Gozewijn D Laverman, Harald Mischak, Gerjan Navis, Giel Nijpels, Marina Noutsou, Alberto Ortiz, Aneliya Parvanova, Frederik Persson, John R Petrie, Piero L Ruggenenti, Femke Rutters, Ivan Rychlík, Justyna Siwy, Goce Spasovski, Marijn Speeckaert, Matias Trillini, Petra Zürbig, Heiko von der Leyen, Peter Rossing, Silke Zimmermann, Brit Rädisch, Anika Hävemeier, Annette Busmann, Ulrike Wittkop, Barbara Neuhaus, Regina Ax-Smolarski, Veit Zieglschmid, Eva Bollweber, Heidrun Wölk, Viktor R Curovic, Ninna H Tougaard, Mie K Eickhoff, Sascha Pilemann-Lyberg, Signe A Winther, Signe V Rosenlund, Tine W Hansen, Bernt J von Scholten, Christian S Hansen, Emilie H Zobel, Jens C Laursen, Simone Theilade, Lone Jelstrup, Tina R Juhl, Dorthe Riis, Jessie A Hermann, Anne G Lundgaard, Maja LD Halkjær, Lene Aabo, Therese Frost Lerche, Maria Lajer, Rikke J Stefansen, Maria A Campbell, Annika Durban, Julia Raad, Michael Prigge, Marco Schiemann, Robbie Wilson, Sharon Kean, Elizabeth Douglas, Pamela Surtees, Christina Gant, Stanley MH Yeung, Ilse Hagedoorn, Joanne Flynn, Joe Galloway, Katriona Brooksbank, Carolina Aparicio, Ilian P Iliev, Francesco Nones, Francesca Lo Bue, Daniela Melacini, Daniela Cugini, Silvia Prandini, Verusca Lecchi, Svitlana Yakymchuk, Giulia Gherardi, Alessandro Villa, Davide Villa, Flavio Gaspari, Antonio N Cannata, Silvia Ferrari, Nadia Stucchi, Šárka Albrechtová, Elina Eldeik, Renata Amanaki, Beatriz Fernandez-Fernandez, Jinny Sanchez-Rodriguez, Clotilde Vázquez, Ana B Sanz, Maria D Sanchez-Niño, Adrian M Ramos, Maria Á Gonzalo, Ulrike Schmidt, Gjulsen Selim, Tatjana Gjorgovski, Slavica S Stratrova, Olivera Stojceva-Taneva, Petra Schutten-Westerneng, Brenda Wierbos, Frank Huvers, Anneke K De Bruin, Bruno Lapauw, Elsie de Man, Kelly Rokegem, Sabien Inion, Kristin Kreutzmann, Isabelle Dewettinck, Caroline Boukens-de Graaf, Ferrina Clerc-de Jong, Jannet Entius, Marian Nannings, Suzy van Steenderen, Friedrich W Petry, Ceyda Kilic
发表日期
2020/4/1
期刊
The lancet Diabetes & endocrinology
卷号
8
期号
4
页码范围
301-312
出版商
Elsevier
简介
Background
Microalbuminuria is an early sign of kidney disease in people with diabetes and indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic risk classifier (CKD273) score was associated with development of microalbuminuria and whether progression to microalbuminuria could be prevented with the mineralocorticoid receptor antagonist spironolactone.
Methods
In this multicentre, prospective, observational study with embedded randomised controlled trial (PRIORITY), we recruited people with type 2 diabetes, normal urinary albumin excretion, and preserved renal function from 15 specialist centres in ten European countries. All participants (observational cohort) were tested with the CKD273 classifier and classified as high risk (CKD273 classifier score >0·154) or low risk (≤0·154). Participants who were classified as high risk were entered into a randomised controlled trial …
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N Tofte, M Lindhardt, K Adamova, SJL Bakker, J Beige… - The lancet Diabetes & endocrinology, 2020