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To investigate the prevalence of parental stress and psychological wellbeing among parents with autistic children and their associations with dimensions of support system. This is a preliminary cross sectional study which randomly selected parents with clinically diagnosed autistic children. Those parents who attended psycho-education session on management of autistic children at Health Psychology Unit were randomly selected to enroll in the study. Psychological wellbeing, parental stress and dimensions of support system were assessed by using General Health Questionnaire (GHQ-28), Parenting Stress Index (PSI) and Provision Social Relation (PSR), respectively. Of the total 52 parents with autistic child (34 female and 18 male), about 90.4% of parents had significant parenting stress, and 53.8% of parents showed clinical disturbance in psychological wellbeing. Gender (t= 1.67, p= 0.02) and occupation (F= 4.78, p= 0.01) showed statistically significant association with psychological wellbeing. No association found between other socio-demographic factors, parental stress and psychological wellbeing with dimensions of support system among parents with autistic child. Parents with autistic children have high prevalence of stress and psychological disturbances. Interactions of various factors need to be acknowledged and considered in order to reduce the burden of parents with autistic children.