作者
Houda Bahig, Ying Yuan, Abdallah SR Mohamed, Kristy K Brock, Sweet Ping Ng, Jihong Wang, Yao Ding, Kate Hutcheson, Molly McCulloch, Peter A Balter, Stephen Y Lai, Abrahim Al-Mamgani, Jan-Jakob Sonke, Uulke A van der Heide, Christopher Nutting, X Allen Li, Jared Robbins, Mussadiq Awan, Irene Karam, Katherine Newbold, Kevin Harrington, Uwe Oelfke, Shreerang Bhide, Marielle EP Philippens, Chris HJ Terhaard, Andrew J McPartlin, Pierre Blanchard, Adam S Garden, David I Rosenthal, Gary B Gunn, Jack Phan, Guillaume Cazoulat, Michalis Aristophanous, Kelli K McSpadden, John A Garcia, Cornelis AT van den Berg, Cornelis PJ Raaijmakers, Linda Kerkmeijer, Patricia Doornaert, Sanne Blinde, Steven J Frank, Clifton D Fuller
发表日期
2018/11/1
期刊
Clinical and translational radiation oncology
卷号
13
页码范围
19-23
出版商
Elsevier
简介
Background
Current standard radiotherapy for oropharynx cancer (OPC) is associated with high rates of severe toxicities, shown to adversely impact patients’ quality of life. Given excellent outcomes of human papilloma virus (HPV)-associated OPC and long-term survival of these typically young patients, treatment de-intensification aimed at improving survivorship while maintaining excellent disease control is now a central concern. The recent implementation of magnetic resonance image – guided radiotherapy (MRgRT) systems allows for individual tumor response assessment during treatment and offers possibility of personalized dose-reduction. In this 2-stage Bayesian phase II study, we propose to examine weekly radiotherapy dose-adaptation based on magnetic resonance imaging (MRI) evaluated tumor response. Individual patient’s plan will be designed to optimize dose reduction to organs at risk and …
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H Bahig, Y Yuan, ASR Mohamed, KK Brock, SP Ng… - Clinical and translational radiation oncology, 2018