作者
Brunangelo Falini, Cristina Mecucci, Enrico Tiacci, Myriam Alcalay, Roberto Rosati, Laura Pasqualucci, Roberta La Starza, Daniela Diverio, Emanuela Colombo, Antonella Santucci, Barbara Bigerna, Roberta Pacini, Alessandra Pucciarini, Arcangelo Liso, Marco Vignetti, Paola Fazi, Natalia Meani, Valentina Pettirossi, Giuseppe Saglio, Franco Mandelli, Francesco Lo-Coco, Pier-Giuseppe Pelicci, Massimo F Martelli
发表日期
2005/1/20
期刊
New England Journal of Medicine
卷号
352
期号
3
页码范围
254-266
出版商
Massachusetts Medical Society
简介
Background
Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations involving the NPM gene cause cytoplasmic dislocation of the NPM protein.
Methods
We used immunohistochemical methods to study the subcellular localization of NPM in bone marrow–biopsy specimens from 591 patients with primary acute myelogenous leukemia (AML). We then correlated the presence of cytoplasmic NPM with clinical and biologic features of the disease.
Results
Cytoplasmic NPM was detected in 208 (35.2 percent) of the 591 specimens from patients with primary AML but not in 135 secondary AML specimens or in 980 hematopoietic or extrahematopoietic neoplasms other than AML. It was associated with a wide spectrum of morphologic subtypes of the disease, a normal karyotype, and responsiveness to induction …
引用总数
学术搜索中的文章
B Falini, C Mecucci, E Tiacci, M Alcalay, R Rosati… - New England Journal of Medicine, 2005
B Falini, C Mecucci, E Tiacci, M Alcalay, R Rosati… - … nucleophosmin in acute myelogenous leukemia with a …, 2005
B Falini - New England Journal of Medicine, 2005