作者
John S Wyatt, Peter D Gluckman, Ping Y Liu, Denis Azzopardi, Roberta Ballard, A David Edwards, Donna M Ferriero, Richard A Polin, Charlene M Robertson, Marianne Thoresen, Andrew Whitelaw, Alistair J Gunn, CoolCap Study Group
发表日期
2007/5/1
期刊
Pediatrics
卷号
119
期号
5
页码范围
912-921
出版商
American Academy of Pediatrics
简介
OBJECTIVE. The goal of this study was to evaluate the role of factors that may determine the efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal encephalopathy.
METHODS. A total of 218 term infants with moderate to severe neonatal encephalopathy plus abnormal amplitude-integrated electroencephalographic recordings, assigned randomly to head cooling for 72 hours, starting within 6 hours after birth (with the rectal temperature maintained at 34.5 ± 0.5°C), or conventional care, were studied. Death or severe disability at 18 months of age was assessed in a multicenter, randomized, controlled study (the CoolCap trial).
RESULTS. Treatment, lower encephalopathy grade, lower birth weight, greater amplitude-integrated electroencephalographic amplitude, absence of seizures, and higher Apgar score, but not gender or gestational age, were associated significantly …
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JS Wyatt, PD Gluckman, PY Liu, D Azzopardi, R Ballard… - Pediatrics, 2007