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Parkinson's disease (PD) is a neurological disorder that affects millions of people worldwide. Among its motor symptoms are bradykinesia, tremors, rigidity, and postural instability. Handwriting variations known as “Parkinsonian handwriting” or “micrographia” are frequently linked to Parkinson's disease. The condition is characterized by tiny, cramped handwriting that gets smaller with time. The illness may make writing challenging and frequently results in less readable text. Innovative handwriting markers are becoming more and more popular as methods for diagnosing and monitoring PD. A new handwriting marker-based Parkinson's disease decision support system is covered in this chapter, with an emphasis on how useful it may be for early detection and tracking.