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Introduction 3. Human ST involved in the synthesis of sialylated TACA 3.1. The β-galactoside α2, 3-sialyltransferases (ST3Gal) 3.2. The β-galactoside α2, 6-sialyltransferases (ST6Gal) 3.3 The GalNAc α2, 6-sialyltransferasses (ST6GalNAc) 3.4. The α2, 8-sialyltransferases (ST8Sia) 4. Investigation-tools to study sialylation changes and STs in cancer 4.1. Linkage and sialylated products formed: Use of lectins and antibodies 4.2. ST enzymatic activities and ST mRNAs: Use of enzymatic assays, Q-PCR, microarrays 4.3. Use of chemical inhibitors of ST activities and ST antisense oligodeoxynucleotides 5. Mechanisms of ST regulation